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Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 19-24 doi: 10.1007/s11684-008-0005-2

Abstract: the effects of RNA interference (RNAi) targeting angiotensin 1a receptor (AT1a) on blood pressure and cardiachypertrophy of rats with renovascular hypertension.targeting AT1a receptor inhibits the development of renovascular hypertension and the accompanying cardiachypertrophy.

Keywords： therapy     Sprague     administration     cardiac hypertrophy     valsartan    

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Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 444-456 doi: 10.1007/s11684-015-0421-z

Abstract:

Ventricular hypertrophy is a powerful and independent predictor of cardiovascular morbid events.A cardiomyocyte hypertrophy model induced by angiotensin II (10 nmol·L−1) wasChanges in the cardiac structure and function were assessed through echocardiography and transmissionmitochondria, and the increased surface area in in vivo and in vitro hypertrophy

Keywords： aspirin     Akt     cardiac hypertrophy     GSK-3β     Wnt/β-catenin    

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Integrated management of cardiac failure: the cardiac failure clinic

Daniel LOISANCE

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 20-25 doi: 10.1007/s11684-011-0106-1

Abstract:

The prevalence of the risk factors and the risk of cardiac failure are both increasing in China.The wide range of clinical presentations of cardiac failure (acute or chronic) and of therapeutic approachesintegration within the same structure of the various experts involved in the diagnosis and the treatment of cardiacIn these centers, collaboration should replace competition between the medical and the surgical cardiac

Keywords： cardiac failure     cardiac transplantation     mechanical circulatory support    

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Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

Frontiers of Medicine   Pages 939-956 doi: 10.1007/s11684-023-0987-9

Abstract: To this end, 12 645 cardiac cells were generated from embryonic day 17.5 and postnatal days 2 and 8 miceThree cardiac developmental paths were identified: two switching to cardiomyocytes (CM) maturation withThese findings could improve the understanding of MNDCM heterogeneity and cardiac development, thus providingnew clues for approaches to effective cardiac regeneration.

Keywords： mononuclear diploid cardiomyocytes     cell–cell communication     cardiac fibroblast     single-cell RNA sequencing     cardiac regeneration    

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Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 58-67 doi: 10.1007/s11684-022-0937-y

Abstract: Kaplan–Meier estimates showed that recipients with cardiac abnormalities had a significantly increasedAfter adjusting for potential confounders, cardiac abnormality was shown to be independently associated

Keywords： cardiac disease     mortality     aged population     lung transplantation    

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Management of mantle cell leukemia with cardiac involvement leading to cardiogenic shock

Muhammad Furqan,Yamei Chen,Akintunde Akinleye,Judy Sarungbam,Alan Gass,Karen Seiter,Delong Liu

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 254-258 doi: 10.1007/s11684-014-0319-1

Abstract: Here we report a case of cardiac involvement by mantle cell leukemia leading to cardiogenic shock which

Keywords： mantle cell lymphoma     bendamustine     cardiogenic shock    

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Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 445-455 doi: 10.1007/s11684-014-0378-3

Abstract: The purpose of this study was to investigate the effects of PDE5 inhibitor on cardiac fibrosis.In control mice, 4 weeks of TAC induced significant cardiac dysfunction, cardiac fibrosis, and cardiacSildenafil treatment markedly prevented TAC-induced cardiac dysfunction, cardiac fibrosis and cardiacIn isolated cardiac fibroblasts, sildenafil blocked TGF-β1-induced cardiac fibroblast transformationthrough CREB activation in cardiac fibroblasts.

Keywords： PDE5     cardiac fibrosis     TGF-β     CREB    

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PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 399-403 doi: 10.1007/s11684-014-0380-9

Abstract:

We review here the novel cardiac protective effects of the multifunctional enzyme, p21-activated kinasereview, we assemble an overview of the recent findings on PAK1 signaling in the heart, particularly its cardiacWe present a model for PAK1 signaling that provides a mechanism for specifically affecting cardiac cellularWe discuss the anti-adrenergic and antihypertrophic cardiac protective effects of PAK1, as well as its

Keywords： p21-activated kinase 1 (PAK1)     heart    

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Right coronary occlusion following transcatheter aortic valve implantation: two case reports

Gang Zhang,Jun Luo,Guo Chen

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 351-355 doi: 10.1007/s11684-016-0465-8

Abstract:

This paper discusses two male patients with severe aortic stenosis, whose right coronary arteries (RCA) were completely occluded during transcatheter aortic valve implantation (TAVI), leading to fatal hemodynamic disorder. Occlusions of RCA complicated by TAVI are rare. In addition, emergency cardiopulmonary bypass (CPB) played a critical role in rescuing our second patient. Both patients were admitted for “severe aortic stenosis,” and TAVIs were performed. The first patient’s blood pressure immediately dropped to 70/40 mmHg after the balloon expansion and did not increase much after the administration of aramine or fluid therapy. He did not receive emergency surgery and died after 1.5 h of resuscitation. The second patient’s blood pressure fluctuated greatly for several minutes after the valve implantation, ranging from 170/100 mmHg to 60/40 mmHg. Angiography revealed a total occlusion of RCA. Thoracic surgery with CPB was performed, and the patient survived.

Keywords： aortic stenosis     transcatheter aortic valve implantation     right coronary occlusion     cardiac group    

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Cardiac Remote Conditioning and Clinical Relevance: All Together Now! Review

Kristin Luther,Yang Song,Yang Wang,Xiaoping Ren,W. Keith Jones

Engineering 2015, Volume 1, Issue 4,   Pages 490-499 doi: 10.15302/J-ENG-2015117

Abstract: cardioprotective “conditioning” phenomena represent activation from different entry points of a cardiacand nociceptive stimuli is emerging as a potential non-ischemic and non-traumatic means to initiate cardiac

Keywords： remote cardioprotection     cardiac conditioning     non-ischemic conditioning     peripheral nociceptive stimulus    

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Familial amyloid cardiomyopathy masquerading as chronic Guillain-Barre syndrome: things are not always what they seem

Die Hu, Ling Liu, Shuguang Yuan, Yuhong Yi, Daoquan Peng

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 293-296 doi: 10.1007/s11684-017-0516-9

Abstract: diseases, particularly in patients with pronounced neurological presentations and unexplained or equivocal cardiacanalysis, explained the concurrence of independent pathological features, including neuropathy and cardiac

Keywords： transthyretin (TTR) cardiac amyloidosis     sick sinus syndrome     chronic Guillain-Barre syndrome    

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Challenges and opportunities in improving left ventricular remodelling and clinical outcome following surgical and trans-catheter aortic valve replacement

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 416-437 doi: 10.1007/s11684-021-0852-7

Abstract: LV hypertrophy and myocardial fibrosis remains as the structural and morphological focus in this endeavourregurgitation along with therapy of angiotensin receptor blockade will improve patient outcome by facilitating hypertrophy

Keywords： surgical aortic valve replacement     trans-catheter aortic valve implantation     left ventricular hypertrophy    

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Application of Biomaterials in Cardiac Repair and Regeneration Review

Zhi Cui,Baofeng Yang,Ren-Ke Li

Engineering 2016, Volume 2, Issue 1,   Pages 141-148 doi: 10.1016/J.ENG.2016.01.028

Abstract: Biomaterials, both natural and synthetic, exhibit great potential in cardiac repair and regeneration,

Keywords： Myocardial infarction     Heart regeneration     Biomaterial     Tissue engineering     Stem cell    

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Visual recognition of cardiac pathology based on 3D parametric model reconstruction Research Article

Jinxiao XIAO, Yansong LI, Yun TIAN, Dongrong XU, Penghui LI, Shifeng ZHAO, Yunhe PAN

Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 9,   Pages 1324-1337 doi: 10.1631/FITEE.2200102

Abstract: Visual recognition of cardiac images is important for and treatment.A new method for classification of cardiac pathology is therefore proposed based on reconstruction.First, 3D heart models are reconstructed based on multiple 3D volumes of cardiac imaging data at theFinally, shape and motion features of 3D heart models across two phases are extracted to classify cardiacComprehensive experiments on the automated cardiac diagnosis challenge (ACDC) dataset of the Statistical

Keywords： 3D visual knowledge     3D parametric model     Cardiac pathology diagnosis     Data augmentation    

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Domain knowledge enhanced deep learning for electrocardiogram arrhythmia classification Research Article

Jie SUN,sunjie@nbut.edu.cn

Frontiers of Information Technology & Electronic Engineering 2023, Volume 24, Issue 1,   Pages 59-72 doi: 10.1631/FITEE.2100519

Abstract: Deep learning provides an effective way for automatic classification of s, but in , pure data-driven methods working as black-boxes may lead to unsatisfactory results. A promising solution is combining with deep learning. This paper develops a flexible and extensible framework for integrating with a deep neural network. The model consists of a deep neural network to capture the statistical pattern between input data and the ground-truth label, and a knowledge module to guarantee consistency with the . These two components are trained interactively to bring the best of both worlds. The experiments show that the is valuable in refining the neural network prediction and thus improves accuracy.

Keywords： Domain knowledge     Cardiac arrhythmia     Electrocardiogram (ECG)     Clinical decision-making    

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Title Author Date Type Operation

Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

Journal Article

Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Journal Article

Integrated management of cardiac failure: the cardiac failure clinic

Daniel LOISANCE

Journal Article

Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

Journal Article

Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients

Journal Article

Management of mantle cell leukemia with cardiac involvement leading to cardiogenic shock

Muhammad Furqan,Yamei Chen,Akintunde Akinleye,Judy Sarungbam,Alan Gass,Karen Seiter,Delong Liu

Journal Article

Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Journal Article

PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Journal Article

Right coronary occlusion following transcatheter aortic valve implantation: two case reports

Gang Zhang,Jun Luo,Guo Chen

Journal Article

Cardiac Remote Conditioning and Clinical Relevance: All Together Now!

Kristin Luther,Yang Song,Yang Wang,Xiaoping Ren,W. Keith Jones

Journal Article

Familial amyloid cardiomyopathy masquerading as chronic Guillain-Barre syndrome: things are not always what they seem

Die Hu, Ling Liu, Shuguang Yuan, Yuhong Yi, Daoquan Peng

Journal Article

Challenges and opportunities in improving left ventricular remodelling and clinical outcome following surgical and trans-catheter aortic valve replacement

Journal Article

Application of Biomaterials in Cardiac Repair and Regeneration

Zhi Cui,Baofeng Yang,Ren-Ke Li

Journal Article

Visual recognition of cardiac pathology based on 3D parametric model reconstruction

Jinxiao XIAO, Yansong LI, Yun TIAN, Dongrong XU, Penghui LI, Shifeng ZHAO, Yunhe PAN

Journal Article

Domain knowledge enhanced deep learning for electrocardiogram arrhythmia classification

Jie SUN,sunjie@nbut.edu.cn

Journal Article